Kirkland was nominated for the Academy Award for Best Actress for her performance in Anna (1987), but lost to Cher, who won for her role in Moonstruck. She won the Golden Globe for Best Performance by an Actress in a Motion Picture – Drama for her role and received awards from the Los Angeles Film Critics Association, and the Independent Spirit Awards. She earned a second Golden Globe nomination for Best Performance by an Actress in a Miniseries or Motion Picture Made for Television for The Haunted (1991). Kirkland is also known for her roles in Cold Feet (1989), Best of the Best (1989), JFK (1991) and Bruce Almighty (2003).
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