In film she appeared in I'm Gonna Git You Sucka and Don't Be a Menace to South Central While Drinking Your Juice in the Hood (both directed by her brother Keenen) and had a starring role in the art film Talking About Sex and later co-starred in Juwanna Mann as Latisha Jansen. She starred with her siblings on the Fox variety show In Living Color and A Low Down Dirty Shame.
Her other television work includes regular appearances on the sitcom In the House with LL Cool J and a recurring role on A Different World. Recently, she has worked as a story editor on her brother Damon's sitcom My Wife and Kids. In 2008, she co wrote a series of children's books with her husband Kevin Knotts, entitled Amy Hodgepodge, about a multiracial girl adjusting to life in public school after years of homeschooling.
In December 2011, she got a chance to showcase her dramatic chops with a supporting role as a mother who struggles to understand her seventeen-year-old daughter in Pariah. She was nominated (alongside co star Pernell Walker) for Best Supporting Actress at the 2012 Black Reel Awards but lost to Octavia Spencer for The Help.